王朝

基本情况:
    2009年本科毕业于hbs红宝石平台,获生物工程专业工学学士学位。2009年至2014年,于香港科技大学生物化学系进行博士学习,获生物化学博士学位。现任中国科学技术大学生命科学与医学部教授、博士生导师
,主要研究方向为神经结构化学生物学,通过系统性地研究神经系统中重要的支架蛋白介导的蛋白复合物的结构功能和化学生物学调控,来深入理解神经细胞极性建立与维持,以及神经网络环路调控的分子机制,并为神经系统疾病的发病机理和药物开发等提供理论基础。近年来在Nat Chem Biol (2018)、Nat Metab (2021)、Nat Commun (2021)、PNAS (2020,2021) 等杂志发表多篇通讯作者文章。主持基金委优青、重大研究计划培育项目、面上项目(2项)等,获得科技部重点研发计划“蛋白质机器与生命过程调控”重点专项资助。


研究方向:

神经结构生物学 

1. 参与调控神经信号转导的重要蛋白复合物的组装和转运等的分子机制

2. 重要架构蛋白对神经细胞极性以及神经网络环路的调控的分子机理

3. 常见神经系统疾病的发病机理以及药物研发的生物学基础

 

近年代表性论文:(#第一作者;*通讯作者)

1.

Zhang X#, Li N#, Zhang J#, Zhang Y#, Yang X#, Luo Y, Zhang B, Xu Z, Zhu Z, Yang X, Yan Y, Lin B, Wang S, Chen D, Ye C, Ding Y, Lou M, Wu Q, Hou Z, Zhang K, Liang Z, Wei A, Wang B, Wang C, Jiang N, Zhang W, Xiao G, Ma C, Ren Y, Qi X, Han W, Wang C*, and Rao F*. 5-IP7 is a GPCR messenger mediating neural control of synaptotagmin-dependent insulin exocytosis and glucose homeostasis. Nat Metab. 2021, 3(10):1400-1414.

2.

Ye J#, Zou G#, Zhu R, Kong C, Miao C, Zhang M, Li J*, Xiong W*, and Wang C*. Structural basis of GABARAP-mediated GABAA receptor trafficking and functions on GABAergic synaptic transmission. Nat Commun. 2021, 12:297.

3.

Zhang M#, Lin L#, Wang C*, and Zhu J*. Double inhibition and activation mechanisms of Ephexin family RhoGEFs. PNAS. 2021, 118(8):e2024465118.

4.

Ye J#, Li J#, Ye F, Zhang Y, Zhang M, and Wang C*. Mechanistic insights into the interactions of dynein regulator Ndel1 with neuronal ankyrins and implications in polarity maintenance. PNAS. 2020, 117(2):1207-1215.

5.

Li J#, Zhu R#, Chen K, Zheng H, Zhao H, Yuan C, Zhang H*, Wang C*, and Zhang M*. Potent and specific Atg8-targeting autophagy inhibitory peptides from giant ankyrins. Nat Chem Biol. 2018, 14(8):778–787.

6.

Zhang Y#, Zhong Z#, Ye J*, and Wang C*. Crystal structure of the PDZ4 domain of MAGI2 in complex with PBM of ARMS reveals a canonical PDZ recognition mode. Neurochem Int. 2021, 149:105152.

7.

Wang M#, Lin L#, Shi Y, He L, Wang C*, and Zhu J*. Structure of the FERM domain of a neural scaffold protein FRMPD4 implicated in X-linked intellectual disability. Biochem J. 2020, 477(23):4623-4634.

8.

Zhang Q, Zhang J, Ye J, Li X, Liu H, Ma X, Wang C, He K, Zhang W, Yuan J, Zhao Y, Xu H*, and Liu Q*. Nuclear speckle specific hnRNP D-like prevents age- and AD-related cognitive decline by modulating RNA splicing. Mol Neurodegener. 2021, 16(1):66.

9.

Huang Y, Wang H, Hao Y, Lin H, Dong M, Ye J, Song L, Wang Y, Li Q, Shan B, Jiang Y, Li H, Shao Z, Kroemer G, Zhang H, Bai L, Jin T, Wang C, Ma Y, Cai Y, Ding C, Liu S*, Pan Y*, Jiang W*, and Zhou R*. Myeloid PTEN promotes chemotherapy-induced NLRP3-inflammasome activation and antitumour immunity. Nat Cell Biol. 2020, 22(6):716-727.

10.

Nelson AD, Caballero-Florán RN, Rodríguez Díaz JC, Hull JM, Yuan Y, Li J, Chen K, Walder KK, Lopez-Santiago LF, Bennett V, McInnis MG, Isom LL, Wang C, Zhang M, Jones KS, and Jenkins PM*. Ankyrin-G regulates forebrain connectivity and network synchronization via interaction with GABARAP. Mol Psychiatry. 2020, 25(11):2800-2817.

11.

Zhu W#, Wang C#, Hu J#, Wan R, Yu J, Xie J, Ma J, Guo L, Ge J, Qiu Y, Chen L, Liu H, Yan X, Liu X, Ye J, He W, Shen Y, Wang C, Mohler PJ*, and Hong K*. Ankyrin-B Q1283H variant linked to arrhythmias via loss of local protein phosphatase 2A activity causes ryanodine receptor hyperphosphorylation. Circulation. 2018, 138(23):2682-2697.

 

整理日期:2022年7月15日

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